Publications
2024
Inflammasome diversity: exploring novel frontiers in the innate immune response.
G. Yu, Y. Choi, S. Lee, Trends in Immunology, Mar 21, 2024:S1471-4906(24)00029-2. (doi: 10.1016/j.it.2024.02.004) (PMID:38519271)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2024]
2023
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation
and assembly drive PANoptosis.
S. Oh, J. Lee, J. Oh, G. Yu, H. Ryu, D. Kim, S. Lee, Cell. Mol. Immunol, Nov 27, 2023; (doi: 10.1038/ s41423-023-01107-9) (PMID:38008850)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2023]
Recent advances in ZBP1-derived PANoptosis aganist viral infections.
S. Oh, S. Lee, Front. Immunol, May 16, 2023; 14:1148727. (doi: 10.3389/ fimmu. 2023.1148727) (PMID:37261341)
2022
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection.
R. Karki*, S. Lee*, R. Mall, N. Pandian, Y. Wang, B. Sharma, R. Malireddi, D. Yang, S. Trifkovic, J. A Steele, J. P Connelly, G. Vishwanath, M. Sasikala, D. N. Reddy, P. Vogel, S. M Pruett-Miller, R. Webby, C. B. Jonsson, T. Kanneganti (*co-first authors), Sci Immunol, May 19, 2022;eabo6294. (doi: 10.1126/sciimmunol.abo6294) (PMID:35587515)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2022]
Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method.
Y. Wang, N. Pandian, J. Han, B. Sundaram, S. Lee, R. Karki, C. S. Guy, T. Kanneganti, Cell Mol Life Sci, Sept. 18. 2022 (DOI: 10.1007/s00018-022-04564-z) (PMID:36169732)
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation.
Y. Wang, R. Karki, R. Mall, B. R. Sharma, R. C. Kalathur, S. Lee, B. Kancharana, M. So, K. L. Combs, T. Kanneganti, Cell Rep, Oct. 4. 2022 (doi: 10.1016/j.celrep.2022.111434) (PMID: 36198273)
2021
Targeting MicroRNA--485-3p blocks Alzheimer’s disease progression S. Han*, S. Lee*, H. Lee, J. Min, T. Iwatsubo, C. Teunissen, H. Cho, J. Ryu (*equal contribution) International Journal of Molecular Sciences, Dec. 4. 2021 (https://doi.org/10.3390/ijms222313136) (PMID: 34884940)
Caspase-8 is a lynchpin in caspase-3 and gasdermin D activation to control cell death, cytokine release, and host defense during influenza A virus infection Y. Wang, R. Karki, M. Zheng, B. Kancharana, S. Lee, S. Kesavardhana, B.S. Hansen, S.M. PruettMiller, and T.D. Kanneganti Journal of Immunology, Nov. 15. 2021 (doi: 10.4049/jimmunol.2100757) (PMID: 34663620)
ADAR1 restricts ZBP1–mediated immune response and PANoptosis to promote tumorigenesis R. Karki, B. Sundaram, B.R. Sharma, S. Lee, R.K.S. Malireddi, L.N. Nguyen, S. Christgen, M. Zheng, Y. Wang, P. Samir, G. Neale, P. Vogel, T.D. Kanneganti Cell Report, Oct. 19. 2021 (doi: 10.1016/j.celrep.2021.109858) (PMID: 34686350)
Innate immunity and cell death in Alzheimer’s disease S. Lee, H. Cho, J. Ryu ASN Neuro, Sept. 21. 2021 (doi: 10.1177/17590914211051908) (PMID: 34668411)
AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense S. Lee, R. Karki, Y. Wang, L. Nguyen, R. Kalathur, and T.D. Kanneganti Nature, Sept. 01, 2021 (https://doi.org/10.1038/s41586-021-03875-8) (PMID: 34471287)
Influenza Viruses : Innate Immunity and mRNA Vaccine S. Lee and J. Ryu Frontiers in Immunology, Aug. 31, 2021 (doi: 10.3389/fimmu.2021.710647) (PMID:34531860)
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes. S. Lee, A. Ishitsuka, T. Kuroki, Y. Lin, A. Shibuya, T. Hongu, Y. Funakoshi, Y. Kanaho, K. Nagata, and A. Kawaguchi JCI insight, Aug. 23, 2021 (doi: 10.1172/jci.insight.139190)
Inflammatory cell death, PANoptosis, mediated by cytokines in diverse cancer lineages inhibits tumor growth. R. K. Malireddi, R. Karki, B. Sundaram, B. Kancharana, S. Lee, P. Samir, and T.D. Kanneganti ImmunoHorizons July 1, 2021, 5 (7) 568-580; (doi: https://doi.org/10.4049/immunohorizons.2100059) (PMID: 34290111)
2020
Coronaviruses : Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines. S. Lee, R. Channappanavar, and T. D. Kannenganti Trends in Immunology, 2020, Oct (https://doi.org/10.1016/j.it.2020.10.005) (PMID: 33153908)
*The paper is selected as a BEST OF TRENDS IN IMMUNOLOGY 2020 . *BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2020]
PANoptosis in microbial infection. D. E. Place, S. Lee, and T. D. Kanneganti Current Opinion in Microbiology, 2020, Aug; (doi: https://doi.org/10.1016/j.mib.2020.07.012) (PMID: 32829024)
2019
Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. S. Lee, A. Ishitsuka, M. Noguchi, M. Hirohama, Y. Fujiyasu, P. Petric, M. Schwemmle, P. Staeheli, K. Nagata, and A. Kawaguchi Science Immunology, 2019 Oct 25;4(40). pii: eaau4643. (doi: 10.1126/sciimmunol.aau4643)(PMID: 31653718)
*Press Release 1. https://www.amed.go.jp/en/news/release_20191026.html
2. https://european-biotechnology.com/up-to-date/latest-news/news/researchers-identify-viralinflammation-switch.html
2018
Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitinspecific protease 8 in lung adenocarcinoma Y. Kim, A. Shiba-Ishii, T. Nakagawa, S. Iemura, T. Natsume, N. Nakano, R. Matsuoka, S. Sakashita, S. Lee, A. Kawaguchi, Y. Sato, M. Noguchi Oncogene, 2018 Oct;37(40):5387-5402. doi: 10.1038/s41388-018-0342-9. (PMID: 29880877)
Influenza A virus infection triggers pyroptosis and apoptosis of respiratory epithelial cells through the type I IFN signaling pathway in a mutually exclusive manner S. Lee, M. Hirohama, M. Noguchi, K. Nagata, A. Kawaguchi Journal of Virology, 2018 Jun 29;92(14). (doi: 10.1128/JVI.00396-18) (PMID: 29743359)
Inhibition of influenza virus infection by Lentinus edodes mycelia extract through its direct action and immunopotentiating activity T. Kuroki, S. Lee, M. Hirohama, T. Taku, M. Kumakura, T. Haruyama, K. Nagata, A. Kawaguchi Frontiers in Microbiology, 2018 May 29;9:1164. doi: 10.3389/fmicb.2018.01164. (PMID: 29910790)