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AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense S. Lee, R. Karki, Y. Wang, L. Nguyen, R. Kalathur, and T.D. Kanneganti Nature, Sept. 01, 2021 ( (PMID: 34471287) *Press Release 1. new-frontier-in-innate-immune-responses.html *Nature Korea Highlight *BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2021]

Innate immunity and cell death in Alzheimer’s disease S. Lee, H. Cho, J. Ryu ASN Neuro, Sept. 21. 2021 (doi: 10.1177/17590914211051908) (PMID: 34668411)

ADAR1 restricts ZBP1–mediated immune response and PANoptosis to promote tumorigenesis R. Karki, B. Sundaram, B.R. Sharma, S. Lee, R.K.S. Malireddi, L.N. Nguyen, S. Christgen, M. Zheng, Y. Wang, P. Samir, G. Neale, P. Vogel, T.D. Kanneganti Cell Report, Oct. 19. 2021 (doi: 10.1016/j.celrep.2021.109858) (PMID: 34686350)

Caspase-8 is a lynchpin in caspase-3 and gasdermin D activation to control cell death, cytokine release, and host defense during influenza A virus infection Y. Wang, R. Karki, M. Zheng, B. Kancharana, S. Lee, S. Kesavardhana, B.S. Hansen, S.M. PruettMiller, and T.D. Kanneganti Journal of Immunology, Nov. 15. 2021 (doi: 10.4049/jimmunol.2100757) (PMID: 34663620)

Targeting MicroRNA--485-3p blocks Alzheimer’s disease progression S. Han*, S. Lee*, H. Lee, J. Min, T. Iwatsubo, C. Teunissen, H. Cho, J. Ryu (*equal contribution) International Journal of Molecular Sciences, Dec. 4. 2021 ( (PMID: 34884940)

Influenza Viruses : Innate Immunity and mRNA Vaccine S. Lee and J. Ryu Frontiers in Immunology, Aug. 31, 2021 (doi: 10.3389/fimmu.2021.710647)


Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes S. Lee, A. Ishitsuka, T. Kuroki, Y. Lin, A. Shibuya, T. Hongu, Y. Funakoshi, Y. Kanaho, K. Nagata, and A. Kawaguchi JCI insight, Aug. 23, 2021 (doi: 10.1172/jci.insight.139190)

(PMID: 34423792)

Inflammatory cell death, PANoptosis, mediated by cytokines in diverse cancer lineages inhibits tumor growth R. K. Malireddi, R. Karki, B. Sundaram, B. Kancharana, S. Lee, P. Samir, and T.D. Kanneganti ImmunoHorizons July 1, 2021, 5 (7) 568-580; (doi: (PMID: 34290111)



Coronaviruses : Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines S. Lee, R. Channappanavar, and T. D. Kannenganti Trends in Immunology, 2020, Oct ( (PMID: 33153908) *The paper is selected as a BEST OF TRENDS IN IMMUNOLOGY 2020 ( *BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2020]

PANoptosis in microbial infection. D. E. Place, S. Lee, and T. D. Kanneganti Current Opinion in Microbiology,, 2020, Aug; (doi: (PMID: 32829024)



Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium S. Lee, A. Ishitsuka, M. Noguchi, M. Hirohama, Y. Fujiyasu, P. Petric, M. Schwemmle, P. Staeheli, K. Nagata, and A. Kawaguchi Science Immunology, 2019 Oct 25;4(40). pii: eaau4643. (doi: 10.1126/sciimmunol.aau4643)

(PMID: 31653718) *Press Release 1. 2. *BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2019]



Influenza A virus infection triggers pyroptosis and apoptosis of respiratory epithelial cells through the type I IFN signaling pathway in a mutually exclusive manner S. Lee, M. Hirohama, M. Noguchi, K. Nagata, A. Kawaguchi Journal of Virology, 2018 Jun 29;92(14). (doi: 10.1128/JVI.00396-18) (PMID: 29743359)

Inhibition of influenza virus infection by Lentinus edodes mycelia extract through its direct action and immunopotentiating activity T. Kuroki, S. Lee, M. Hirohama, T. Taku, M. Kumakura, T. Haruyama, K. Nagata, A. Kawaguchi Frontiers in Microbiology, 2018 May 29;9:1164. doi: 10.3389/fmicb.2018.01164. (PMID: 29910790)

Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitinspecific protease 8 in lung adenocarcinoma Y. Kim, A. Shiba-Ishii, T. Nakagawa, S. Iemura, T. Natsume, N. Nakano, R. Matsuoka, S. Sakashita, S. Lee, A. Kawaguchi, Y. Sato, M. Noguchi Oncogene, 2018 Oct;37(40):5387-5402. doi: 10.1038/s41388-018-0342-9. (PMID: 29880877)

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