Publications
2026
EZH2: an epigenetic governor of T-cell Ca2+ homeostasis.
S. Kim, S. Lee*, (*Correspondence) Cell. Mol. Immunol, June 25, 2026. (doi: 10.1038/s41423-026-01429-4) (PMID:)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2026]
Itaconate induces noncanonical AIM2-dependent PANoptosis
in sepsis.
H. Kim, S. Lee*, (*Correspondence) Cell. Mol. Immunol, June 25, 2026. (doi: 10.1038/s41423-026-01428-5) (PMID:)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2026]
Recent advances in Mpox across innate immunity, evasion, and clinical outcomes.
J. Oh, Y. Chung, S. Lee*, (*Correspondence) Communications Biology, June 15, 2026. (doi: 10.1038/s42003-026-10487-3) (PMID:)
The bidirectional inflammasome-lymphocyte axis in immune regulation.
Y. Kwon, S. Lim, S. Lee*, (*Correspondence) Trends Open, June 5, 2026. (doi: ) (PMID:)
Herpes simplex virus1 harboring poly(T) DNA sequences as a key ligand for AIM2 inflammasome activation and host defense.
S. Oh, J. Oh. K. Im, T. Kim, J. Lee. K. Shin, N. Mariam, C. Seok, J. Park, G. Yu, H. Kim, S. Kim, S. Shin, J. Gil, S. Park, Y. Chung, D. Kim, Y. Choi, E. Kim, J. Lee, S. Lee*, (*Correspondence) Nature communications, Apr 13, 2026. (doi: 10.1038/s41467-026-71896-w) (PMID:41974701)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2026]
*YTN 사이언스 보도
*UNIST 보도
Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease.
Y. Jang, H. Bae, S. Oh, G. Yu, H. Bae, M. Nguyen, R. Mall, M. Fu, A. Ghosh, J. Lee, S. Kim, S. Shin, N. Mariam, C. Seok, D. Kim, S. Lee*, S. Man*, R. Karki*, (*Correspondence) Science Advances, Apr 10, 2026. (doi: 10.1126/sciadv.aea39792026.03.004) (PMID:41961937)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2026]
*YTN 사이언스 보도
*UNIST 보도
https://www.unist.ac.kr/unist/center/resualt.do?mode=view&articleNo=270355
*UNIST 인터뷰 영상
Redefining nucleotide-binding oligomerization domain-like receptors: from immune sentinels to multifunctional regulators.
S. Kim, S. Park, S. Lee* (*Correspondence), Trends in Immunology, Mar 28, 2026. (doi: 10.1016/j.it2026.03.004) (PMID:41904048)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2026]
Defining Iytic IFNγ for deciphering the CTL. mechanism.
J. Park, S. Lee* (*Correspondence), Cell. Mol. Immunol, Mar 25, 2026. (doi: 10.1038/s41423-026-01402-1) (PMID:41876883)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2026]
Antiplatelet activity of a Korean red ginseng-derived saponin fraction and its inhibition of influenza A virus-induced thrombosis.
G. Lee, J. Oh, J. Lee, N. Heo, S. Lee*, D. Lee* (*Correspondence), Journal of Gìnseng Research, Jan 21, 2026. (doi: 10.1016/j.jgr.2026.100981) (PMID:)
2025
Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus.
J. Oh, H. Kim, J. Lee, S. Kim, S. Shin, Y. Kim, S. Park, S. Lee, Journal of Microbiology, Jan 24, 2025;e:2409007. (doi:10.71150/jm.2409007)
Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus.
J. Oh, H. Kim, J. Lee, S. Kim, S. Shin, Y. Kim, S. Park, S. Lee, Journal of Microbiology, Jan 24, 2025;e:2409007. (doi:10.71150/jm.2409007)
2024
Inflammasome diversity: exploring novel frontiers in the innate immune response.
G. Yu, Y. Choi, S. Lee* (*Correspondence), Trends in Immunology, Mar 21, 2024:S1471-4906(24)00029-2. (doi: 10.1016/j.it.2024.02.004) (PMID:38519271)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2024]
2023
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation
and assembly drive PANoptosis.
S. Oh, J. Lee, J. Oh, G. Yu, H. Ryu, D. Kim, S. Lee* (*Correspondence), Cell. Mol. Immunol, Nov 27, 2023; (doi: 10.1038/ s41423-023-01107-9) (PMID:38008850)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2023]
Recent advances in ZBP1-derived PANoptosis aganist viral infections.
S. Oh, S. Lee* (*Correspondence), Front. Immunol, May 16, 2023; 14:1148727. (doi: 10.3389/ fimmu. 2023.1148727) (PMID:37261341)
2022
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection.
R. Karki*, S. Lee*, R. Mall, N. Pandian, Y. Wang, B. Sharma, R. Malireddi, D. Yang, S. Trifkovic, J. A Steele, J. P Connelly, G. Vishwanath, M. Sasikala, D. N. Reddy, P. Vogel, S. M Pruett-Miller, R. Webby, C. B. Jonsson, T. Kanneganti (*co-first authors), Sci Immunol, May 19, 2022;eabo6294. (doi: 10.1126/sciimmunol.abo6294) (PMID:35587515)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2022]
Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method.
Y. Wang, N. Pandian, J. Han, B. Sundaram, S. Lee, R. Karki, C. S. Guy, T. Kanneganti, Cell Mol Life Sci, Sept. 18. 2022 (DOI: 10.1007/s00018-022-04564-z) (PMID:36169732)
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation.
Y. Wang, R. Karki, R. Mall, B. R. Sharma, R. C. Kalathur, S. Lee, B. Kancharana, M. So, K. L. Combs, T. Kanneganti, Cell Rep, Oct. 4. 2022 (doi: 10.1016/j.celrep.2022.111434) (PMID: 36198273)
2021
Microtubule detyrosination links inflammasome activation to apoptotic cell death in macrophages upon influenza A virus infection. J. Kar, M. Hirohama, K. Nakayama, S. Lee, A. Kawaguchi, Journal of Virology, Dec 9, 2025. (doi: 10.1128/jvi.01847-25) (PMID:41363857)
Dysregulation of innate immune sensors and autoinflammation: insights from an NLRC4 mouse AIFEC model.
J. Park, S. Lee* (*Correspondence), Cell. Mol. Immunol, Dec 3, 2025. (doi: 10.1038/s41423-025-01366-8) (PMID:41339480)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2025]
AIM2 drives inflammatory cell death and monkeypox pathogenesis.
J. Oh, Y. Hwang, J. Lee, C. Seok, S. Oh, H. Kim, N. Mariam, J. Ahn, G. Yu, J. Park, H. Kim, S. Kim, S. Shin, M. Jung, J. Gil, J. Lee, Y. Choi, D. Kim, D. Kim, Y. Kim, S. Lee* (*Correspondence), Cell. Mol. Immunol, Nov 12, 2025. (doi: 10.1038/s41423-025-01367-7) (PMID:41225161)
*BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2025]
Prolonged immune activation in post-acute sequelae of SARS-CoV-2: neutrophil dynamics and therapeutic insights.
M. Yu, S. Hwang, H. Jang, D. Park, J. Kim, J. Gil, J. Choi, S. Jang, I. Choi, Y. Jung, W. kwon, S. Kim, Y. Kim, H. Kim, T. Oh, J. Lee, M. Song, S. Lee, Y. Choi, Experimental & Molecular Medicine, September 24, 2025. (doi: 10.1038/s12276-025-01539-5)
Identification of reactive CpGs and RNA expression in early COVID-19 through cis-eQTM analysis reflecting disease severity and recovery.
H. Ryu, K. An, Y. Kwon, S. Jeon, H. Choi, Y. Kim, S. Kim, S. Ok, S. Lee, A.Chun, E. Shin, S. Ra & J. Bhai, Communications biology, August 7, 2025. (doi: 10.1038/s42003-025-08609-4)
Targeting innate immune sensors for therapeutic strategies in infectious diseases.
S. Shin, Y. Choi, S. Lee* (*Correspondence), Journal of Microbiology, June 30, 2025. (doi: 10.71150/jm.2503009) (PMID:40598998)
Pattern recognition receptors and inflammasome : Now and beyond.
S. Oh, Y. Choi, S. Lee* (*Correspondence), Molecules and Cells, June 15, 2025. (doi:10.1016/j.mocell.2025.100239) (PMID:40527410)
CD7-Targeted Cytotoxic Potency of Diphtheria Toxin- and Ricin-Based Immunotoxins in Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia.
H. Lee, S. Park, H. Kim, J. Jeon, S. Oh, S. Lee, S. Park, S. Kang. Molecular Pharmaceutics, May 2, 2025. (doi:10.1021/acs.molpharmaceut.5c00146) (PMID:40317108)
Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus.
J. Oh, H. Kim, J. Lee, S. Kim, S. Shin, Y. Kim, S. Park, S. Lee* (*Correspondence), Journal of Microbiology, Jan 24, 2025;e:2409007. (doi:10.71150/jm.2409007)
*YTN 사이언스 보도
https://www.youtube.com/watch?app=desktop&v=9P3nGqSI5_s&t=2s
Targeting MicroRNA--485-3p blocks Alzheimer’s disease progression S. Han*, S. Lee*, H. Lee, J. Min, T. Iwatsubo, C. Teunissen, H. Cho, J. Ryu (*equal contribution) International Journal of Molecular Sciences, Dec. 4. 2021 (https://doi.org/10.3390/ijms222313136) (PMID: 34884940)
Caspase-8 is a lynchpin in caspase-3 and gasdermin D activation to control cell death, cytokine release, and host defense during influenza A virus infection Y. Wang, R. Karki, M. Zheng, B. Kancharana, S. Lee, S. Kesavardhana, B.S. Hansen, S.M. PruettMiller, and T.D. Kanneganti Journal of Immunology, Nov. 15. 2021 (doi: 10.4049/jimmunol.2100757) (PMID: 34663620)
ADAR1 restricts ZBP1–mediated immune response and PANoptosis to promote tumorigenesis R. Karki, B. Sundaram, B.R. Sharma, S. Lee, R.K.S. Malireddi, L.N. Nguyen, S. Christgen, M. Zheng, Y. Wang, P. Samir, G. Neale, P. Vogel, T.D. Kanneganti Cell Report, Oct. 19. 2021 (doi: 10.1016/j.celrep.2021.109858) (PMID: 34686350)
Innate immunity and cell death in Alzheimer’s disease S. Lee, H. Cho, J. Ryu ASN Neuro, Sept. 21. 2021 (doi: 10.1177/17590914211051908) (PMID: 34668411)
AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense S. Lee, R. Karki, Y. Wang, L. Nguyen, R. Kalathur, and T.D. Kanneganti Nature, Sept. 01, 2021 (https://doi.org/10.1038/s41586-021-03875-8) (PMID: 34471287)
Influenza Viruses : Innate Immunity and mRNA Vaccine S. Lee and J. Ryu Frontiers in Immunology, Aug. 31, 2021 (doi: 10.3389/fimmu.2021.710647) (PMID:34531860)
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes. S. Lee, A. Ishitsuka, T. Kuroki, Y. Lin, A. Shibuya, T. Hongu, Y. Funakoshi, Y. Kanaho, K. Nagata, and A. Kawaguchi JCI insight, Aug. 23, 2021 (doi: 10.1172/jci.insight.139190)
Inflammatory cell death, PANoptosis, mediated by cytokines in diverse cancer lineages inhibits tumor growth. R. K. Malireddi, R. Karki, B. Sundaram, B. Kancharana, S. Lee, P. Samir, and T.D. Kanneganti ImmunoHorizons July 1, 2021, 5 (7) 568-580; (doi: https://doi.org/10.4049/immunohorizons.2100059) (PMID: 34290111)
2020
Coronaviruses : Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines. S. Lee, R. Channappanavar, and T. D. Kannenganti Trends in Immunology, 2020, Oct (https://doi.org/10.1016/j.it.2020.10.005) (PMID: 33153908)
*The paper is selected as a BEST OF TRENDS IN IMMUNOLOGY 2020 . *BRIC: 한국을 빛낸 사람들 (한빛사)에 등재 [2020]
PANoptosis in microbial infection. D. E. Place, S. Lee, and T. D. Kanneganti Current Opinion in Microbiology, 2020, Aug; (doi: https://doi.org/10.1016/j.mib.2020.07.012) (PMID: 32829024)
2019
Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. S. Lee, A. Ishitsuka, M. Noguchi, M. Hirohama, Y. Fujiyasu, P. Petric, M. Schwemmle, P. Staeheli, K. Nagata, and A. Kawaguchi Science Immunology, 2019 Oct 25;4(40). pii: eaau4643. (doi: 10.1126/sciimmunol.aau4643)(PMID: 31653718)
*Press Release 1. https://www.amed.go.jp/en/news/release_20191026.html
2. https://european-biotechnology.com/up-to-date/latest-news/news/researchers-identify-viralinflammation-switch.html
2018
Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitinspecific protease 8 in lung adenocarcinoma Y. Kim, A. Shiba-Ishii, T. Nakagawa, S. Iemura, T. Natsume, N. Nakano, R. Matsuoka, S. Sakashita, S. Lee, A. Kawaguchi, Y. Sato, M. Noguchi Oncogene, 2018 Oct;37(40):5387-5402. doi: 10.1038/s41388-018-0342-9. (PMID: 29880877)
Influenza A virus infection triggers pyroptosis and apoptosis of respiratory epithelial cells through the type I IFN signaling pathway in a mutually exclusive manner S. Lee, M. Hirohama, M. Noguchi, K. Nagata, A. Kawaguchi Journal of Virology, 2018 Jun 29;92(14). (doi: 10.1128/JVI.00396-18) (PMID: 29743359)
Inhibition of influenza virus infection by Lentinus edodes mycelia extract through its direct action and immunopotentiating activity T. Kuroki, S. Lee, M. Hirohama, T. Taku, M. Kumakura, T. Haruyama, K. Nagata, A. Kawaguchi Frontiers in Microbiology, 2018 May 29;9:1164. doi: 10.3389/fmicb.2018.01164. (PMID: 29910790)